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They recognize that clinical trials showed modest effects (average 2.6 kg over 12 weeks in responders), appreciate that individual response varies significantly, commit to proper nutrition and exercise foundations, and accept that the peptide is used for research purposes under medical supervision

Incretin-based therapies are associated with acute pancreatitis: meta-analysis of large randomized controlled trials

Others lose 8-10%

The most common side effects are gastrointestinal, which includes nausea, bloating, constipation, and diarrhea

Oral options are now becoming more important, including oral semaglutide formulations and orforglipron, marketed as Foundayo

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