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It is mainly present in muscle tissue and in the heart, as well as in nerve tissue

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doi: 10.1016/j.mrfmmm.2011.10.008 24 SteadLMBrosnanJTBrosnanMEVanceDEJacobsRL

Notably, at physiological concentrations, TMAO can enhance the integrity of the bloodbrain barrier through the tight junction regulator annexin A1, limit the reactivity of astrocytes and microglia, and protect the cognitive function of mice from inflammatory challenges