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On product loss: peptides can adsorb onto PES membranes, particularly at low concentration (below 100 micrograms/mL) and for hydrophobic sequences

Decreased levels of -KG in GOT1-deficient T cells limit the neutralization of ammonia, resulting in severe T cell dysfunction [71]

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Ultimately, given these dual roles, deciphering NAMPTs function requires an integrated view of metabolic and epigenetic interactions beyond simple NAD + levels

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