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Conversely, the oppositea hyperoxidizing ERelicits comparatively modest UPR activation despite impairing protein maturation and preventing disulfide isomerization ( UPR activation is linked with obesity in several tissues, implying that metabolic activity, or the dysregulation thereof, impacts ER homeostasis

Chan School of Public Healths Nutrition Source, last reviewed March 2023, viewed on May 16, 2023

doi: 10.1165/ajrcmb.17.5.2833

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