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In rats, mGlu 2/3 activation reduces motivation to self-administer cocaine as determined by a reduced breakpoint under a progressive ratio reinforcement schedule (Hao et al., 2010

Based on the data, the LD50 of CGA is 382.28 mg/kg, indicating a safe dosage range for a single intravenous injection of 0125 mg/kg

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Side Effects and Safety Considerations Both compounds are generally well-tolerated in the doses used for research protocols

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