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Access this article Similar content being viewed by others Abbreviations AAPH: Hydrochloride 2,2-azobis-2-amidinopropane AIDS: Acquired immunodeficiency syndrome ARE: Antioxidant response element CAT: Catalase Cu/Zn-SOD: Copper/zinc-superoxide dismutase DIVEMA: Divinyl ether and maleic anhydride DNA: Deoxyribonucleic acid EC-SOD: Extracellular-superoxide dismutase Fe-SOD: Iron-superoxide dismutase FIV: Feline immunodeficiency virus GPx: Glutathione peroxidase H 2 O 2 : Hydrogen peroxide HIV: Human immunodeficiency virus HO: Hydroxyl radical Mn-SOD: Manganese-superoxide dismutase Nrf2: Transcription factor nuclear-factor-E2-related factor O 2 - : Superoxide anion radical PEG: Pegylated PMA: Phorbol 12-myristate 13-acetate ROS: Reactive oxygen species SOD: Superoxide dismutase REFERENCES Davies KJA

When used in combination, NAC and cisplatin may enhance the cytotoxic effects on cancer cells while simultaneously protecting normal cells by mitigating oxidative damage [516, 517], and the combination can also reduce side effects such as ototoxicity caused by cisplatin administration [518]