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[37] However, post-withdrawal in STEP 1 extension, weight regain averaged two-thirds of losses within a year, underscoring the need for ongoing therapy

The pooled weighted mean difference (WMD) was calculated using a random-effects model

Effect of TMAO on macrophage cholesterol biosynthesis, cholesterol efflux, inflammatory genes, and desmosterol levels The effect of cholesterol loading on macrophage cholesterol biosynthetic and inflammation genes, LDL receptor expression levels, and desmosterol levels, were performed as previously described 24

We found no significant association between change in any of our primary 31 P-MRS measures and change in MADRS in any of the regions examined

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