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AOD-9604 suppresses lipogenesis, the production of new fat stores, and increases lipolysis, the breakdown of fat, by mimicking the activity of endogenous hGH in adipose tissue

Free Radic Biol Med 51, 20312040.Google Scholar 450 -hydroxylase pathway of tocopherol catabolism

They can trigger several pro-metastatic signaling cascades, including the NF-B pathway [84], which regulates genes related to cell survival, proliferation, and metastasis, and MAPK pathways that influence cell proliferation, survival, and migration [82]

10.1038/s41586-020-2971-8 75

GAPDH, which is supposed to prevent accumulation of MG, was also found to be a target of MG modification 18 , highlighting the interaction of oxidative stress and cellular metabolism