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The function of Parkin in mitophagy was not fully understood until a key study, carried out in 2008 [172], showed that Parkin facilitates the autophagic clearance of damaged mitochondria by being specifically attracted to mitochondria with diminished m after treatment with a mitochondrial uncoupler [172]

Despite demonstrating biological activity and a favorable safety profile, AOD9604 has not achieved regulatory approval as an obesity therapeutic