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Following treatment with dual-functional NPs, the expression levels of the Nrf2-targeting antioxidant gene SLC7A11 and ROS detoxification genes eg Aldo-keto reductases ( AKR1B1, AKR1C1, AKR1C2 , and AKR1C3) were reduced, sensitising the cells to ferroptosis

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The two primary endpoints were the Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ-CSS, which ranges from 0 to 100) and the Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ-CSS)

These drugs render type 2 diabetes more manageable by lowering insulin resistance and A1C levels through the inhibition of the release of glucagon, a hormone that elevates blood sugar levels