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This deficiency is common, affecting approximately 6% of people under the age of 60 and 20% of people over the age of 60

While less common than flushing, these cardiovascular effects raise understandable concern

Patient Characteristics Most patients in cohort 1 were female (62.2%), and the mean age was 70.4 years (standard deviation [SD],13.2)

doi: 10.1002/1521-3773(20010618)40:12 3.0.CO;2-5

Common symptoms: Swelling in one leg (sometimesboth) Pain or heaviness in the calfor thigh Warmth, redness, or tendernessalong the vein Night cramps or pain whilewalking Complication: If part of the clotbreaks and travels to the lungs, it causes Pulmonary Embolism (PE) a life-threatening emergency

This targeted distribution contributes to the favorable side effect profile relative to systemic weight loss interventions like stimulants