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Thereby, also for anti-glaucoma therapy with essential NO-importance [94], it may be quite indicative of the counteraction of the NO-synthase (NOS)-blocker effect, in particular, and thereby, counteraction of NO-system failure (i.e., retinal ischemia) supposedly particularly damaging for eye function [94,132,133,134,135,136]

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Finally, from a general point of view, the consistent effect of NSAIDs (24, 25), and thereby, the consistent NSAIDs effects on sphincters failure in rat, and vice versa, the consistent sphincter failure related to NSAIDs, thus, a commonality for both NSAIDs and sphincter failure, could be hardly combined with the quite inconsistent effects of NSAIDs on sphincter pressure in different species so far reported (17-23)