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In addition to dioxygenase enzymes that drive histone and DNA demethylation, KG also serves as a substrate for a class of prolyl 4hydroxylase enzymes, which mediate the ubiquitination and degradation of hypoxiainducible factor 1 (HIF1), a key transcription factor that facilitates the cellular adaptation to low oxygen levels (Fig 3)

Loss of muscle mass during preoperative chemotherapy as a prognosticator for poor survival in patients with colorectal liver metastases

these genotype and allele frequencies did not influence the prognosis of AITD

Some studies have shown that Glutathione can inhibit the growth of certain types of cancer cells, suggesting a possible role in cancer therapy

It was believed that a malnourished state depleted hepatic GSH and thus reduced the ability to detoxify NAPQI leading to increased risk of toxicity [73, 76]

Other antimicrobial profiles of essential oils are reported in the literature