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Furthermore, the expression of genes associated with mitochondrial biogenesis, including PGC-1, Nrf1, NRF2, and TFAM, was observed to have decreased in brain tissue samples from AD patients (Kerr et al., 2017)
Since B12 is found solely in animal products, people with restricted diets often get very little B12, even if they eat synthetically fortified foods
JS Park, JH Chyun, YK Kim, LL Line, BP Chew

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Enhanced Antioxidant Recycling As mentioned, antioxidants are used up once they neutralise a free radical