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The second PCA component, loading on glutathione and glutamate scores in the ACC, was therefore our first dependent variable

These challenges, along with potential strategies to overcome them, are summarized in Figure 2, which highlights the translational barriers of NRF2-targeted therapies and outlines proposed solutions such as patient-derived models, selective inhibitors, and biomarker development

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doi: 10.1002/hipo.20470

The study enrolled 36 healthy adults (age 45-65) and administered sermorelin via three routes in randomized order with 2-week washout periods: 300 mcg subcutaneous injection 1500 mcg sublingual tablet (5x the injection dose to attempt bioavailability compensation) Placebo Blood samples were drawn at baseline, 30 minutes, 60 minutes, 90 minutes, and 120 minutes