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We approached these issues by applying (1) affine registration for T1W MRI data and (2) rigid registration to the unbiased MNI152 template on the raw whole brain data and then (3) minimizing the between-cohort appearance difference using a dynamic histogram warping (DHW) algorithm (Cox et al., 1995) as it was demonstrated to be among the best intensity matching methods in medical imaging (Wagenknecht et al., 2000)

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