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Overman, MJ, Yothers, G, Jacobs, S, Sanoff, HK, Cohen, D, Guthrie, KA, Henry, NL, Ganz, PA, Kopetz, S , Lucas, PC, Blanke, CD, Hong, TS, Wolmark, N, Hochster, HS, George, TJ

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31 Some studies reported that APR-246 acts independently of its ability to reactivate mutant p53 protein

3.5 hours (dialysis patients) 33-55 minutes (IV: ~33 min, IM: ~55 min) ~30 minutes (plasma) ~0.5 hours (estimated

67 Non-proliferative astrogliosis typically occurs in neural tissue that is responding to a pathology but is not overtly damaged and retains its basic tissue architecture, for example (i) during diffuse neuroinflammation caused by peripheral exposure to microbial antigens such as lipopolysaccharide (LPS), 68,69 (ii) in tissue regions that are at a distance from focal lesions (diaschisis) caused by stroke, trauma or autoimmune attack, 8,70 or (iii) in tissue undergoing neurodegenerative changes