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As a result, rhGH supplementation is not approved for medical treatment of the pathophysiologic, age-related decline in GH/IGF secretion, despite the clinical similarities with classically defined, adult-onset GHD

[PubMed] [Google Scholar] Cruciani R.A., Dvorkin E., Homel P., Culliney B., Malamud S., Shaiova L., Fleishman S., Lapin J., Klein E., Lesage P., Portenoy R., Esteban-Cruciani N

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