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Likewise, reduction of intracellular pH affects the maintenance of a pH gradient across the cell membrane and provokes loss of energy generation by bacterial metabolism such as respiratory chain (where reduced NADH dehydrogenase, succinic acid dehydrogenase, and reduced ubiquinone cytochrome-c oxidoreductase are inhibited) [18,21-24] and anaerobic glycolysis (which inhibits hexokinase) [6,25]
This possible gene-environment interaction seems to be biologically plausible, since it has been shown that GSTP1 Val allele is more catalytically efficient towards benzo-diol-epoxides found in tobacco smoke 52

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Nipa NS, Ali T, Akhter S, Rafiq K
HirtzRLibudaLHinneyAFckerMBhlmeierJAntelJet alLack of evidence for a relationship between the hypothalamus-pituitary-adrenal and the hypothalamus-pituitary-thyroid axis in adolescent depression
The decline of normal red blood cell production, caused by low levels of vitamin B12, can impair oxygen delivery
