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Acknowledgements We thank Karin Schlegelmilch for constructive discussions and advice on YAP1, Steve Hooper for cloning and Erik Sahai for providing the pBabe YAP1 5SA-YFP plasmid, all members of the Department of Translational Genomics for constructive feedback, Henning Walczak and Manolis Pasparakis for providing recombinant TRAIL and TNF, respectively, Johannes Khle for providing buffy coats and Trudy Oliver for advice