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Dermatologically, both Melanotan I and II can darken moles and cause new lentigines, but multiple case reports and series link Melanotan II use with atypical nevi changes and, in rare cases, melanoma diagnoses temporally associated with use

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It was originally developed in research settings to study photoprotection and as a potential treatment for conditions like erythropoietic protoporphyria, a light-sensitivity disorder

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Lip biting or the sucking action drawing the mucous membranes of the lower lip between the teeth are thought to be common causes

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