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Metabolomic studies in the preclinical ischemic AKI model have shed substantial light on this issue and demonstrated widespread changes in energy metabolism in the kidney as well as remote organs including the heart and lung 6,15, 16

Either dysfunctions or hyperfunctions are implicated in a variety of disorders, particularly congenital sensory neuropathy, sensory neuropathy caused by diabetes, herpes zoster, postherpetic neuralgia, atopic dermatitis, impaired healing of injured tissue (e.g

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The intrinsic pathway is firmly regulated by Bcl-2 family members which includes pro-apoptotic and proteins such as Bax and Bak as well as anti-apoptotic proteins such as BCL-2 [60]

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This cellular protection supports muscle recovery and reduces prolonged inflammatory signaling that can interfere with performance and healing