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Levels may drop as a result of oxidative stress due to disease, drugs, aging, toxic chemicals, inflammation, and stress in general

Grape pomace is a solid organic by-product consisting of grape skin, stem fractions, pulp, and seed, which are discarded in the manufacture of wines or juices and can either be fermented or not [25]

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More lasting benefits develop after multiple treatments

12 Another cause of reduced effectiveness is insufficient oral or gut microorganisms that convert nitrate to nitrite
