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doi: 10.1111/1541-4337.12701, 15
Mechanisms of acetaminophen-induced cell death in primary human hepatocytes
Downregulation of GPX4 and subsequent accumulation of lipid ROS are the key mechanisms through which dihydroartemisinin triggers ferroptosis
This localization theoretically reduces systemic side effects and cancer concerns compared to long-acting analogs, though local effects may still influence surrounding tissues
Nat Cell Biol 28 , 903914 (2026)
