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Under conditions of seizure-induced stress, this system can be thrown out of balance in several ways leading to ferroptosis

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Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth
the transcellular pathway, which involves corneocytes and the lipid matrix around them

Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells
