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The results demonstrated that excessive zinc led to an increased proportion of bi-hormonal INS + ARX + cells and ARX + ZsGreen + cells, further suggesting that zinc accumulation promotes -to- cell transdifferentiation (Supplementary information, Fig

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Many research efforts have been conducted to delay the introduction of levodopa in patients, which has eventually led to the development of dopamine agonists as monotherapy, with a theory stating that the administration of dopamine agonists can delay the development of motor complications if administered before levodopa [20]