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Previous reviews implicate a variety of hyperglycemia-dependent pathways, including the sorbitol, glucosamine and the AGE/RAGE pathways, possibly leading to oxidative stress and induction of inflammatory pathways [5]

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If any, the only difference is that sole sensory neuropathy occurs more frequently in B 12 deficiency

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We found that A2AR deficiency in CD8 + T cells upregulated GPX4 expression (Figure 6, A and B) and A2ARi upregulated gene expression of gpx4 , which was supported by assay for transposase-accessible chromatin using sequencing (ATAC-seq) data showing increased chromatin accessibility within the vicinity of transcribed regions for gpx4 in activated CD8 + T cells upon A2ARi treatment (Figure 6C), pointing to a possible transcriptional regulation of GPX4 expression by inactivation of A2AR signaling

Although Glutathione alone can reduce tyrosinase activity, Vitamin C seems to be a good ally in this mission