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In vivo evaluations of these compounds have been conducted in diverse species, including mice, rats, non-human primates, and chickens, to investigate their effects on conditions such as addiction, aging, Alzheimers disease, autism, epilepsy, Huntingtons disease, ischemia, pain, Parkinsons disease, schizophrenia, and stroke (Cioffi and Guzzo 2016

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The Authors This article is Open Access: CC BY 4.0 licence (

All four therapies included in the study were most effective when they reduced hyperconnectivity between the SCAN and the subcortex, ultimately normalizing activity in the circuit responsible for planning and coordinating action