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However, no published research directly compares continuous versus cycled protocols

Expectation misalignment Expecting dramatic results in the first week sets up disappointment

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The ability to shuttle between the +1, +2, and +3 oxidation states is responsible for the versatile chemistry of vitamin B 12 , allowing it to serve as a donor of deoxyadenosyl radical (radical alkyl source) and as a methyl cation equivalent (electrophilic alkyl source)

However, it never received FDA approval because the results, while positive, weren't dramatic enough to meet regulatory thresholds for an obesity drug

Treatment of vitamin B 12 deficiency