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In the course of this astrogliosis in glaucoma, there is also increased expression of the phagocytosis-related Mac-2 gene and ET-1 by astrocytes, demonstrating both their role in phagocytosis of damaged or dead RGC debris and their involvement in glaucoma-associated vascular dysregulation (Nickells et al., 2012

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Moreover, it can result in the removal of the histone octamers (histone eviction) or replacement with variant histones that are involved in active transcription (histone replacement) [65]

Whilst embelin improved visual recognition in dose dependency manner, it also reduced the level of ACh in a dose-dependent manner as well

20 Routine referral for radiography of patients presenting with low back pain: is patients outcome influenced by GPs referral for plain radiography

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