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In addition, dietary deficiency of vitamin B12 results in megaloblastic anemia accompanied by methylmalonic acidemia

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[176] Prolonged elevations of brain temperature above 40 C likely promote the development of amphetamine-induced neurotoxicity in laboratory animals by facilitating the production of reactive oxygen species, disrupting cellular protein function, and transiently increasing bloodbrain barrier permeability

Several studies have demonstrated that TMAO can stabilize protein metabolism, thereby reducing PERK activity and alleviating ER stress

The deficit in mitochondrial handling of methylmalonyl-CoA that is common to the mut, cblA, and cblB forms of methylmalonic acidemia can be demonstrated in vivo by administration of the precursor, [1-13C]propionate, with measurement of 13CO2 in expired air (11)

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