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Duan Y, Llorente C, Lang S, Brandl K, Chu H, Jiang L, et al

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In brief, molecule 356 was the best candidate to inhibit MAO-A, due to its high affinity for MAO-A ( 12.9 kcal/mol), and low affinity energy for MAO-B ( 8.8 kcal/mol), which indicates good selectivity

Please note that the FDA and EMA first-in-human guidance applies to multiple phases of first in human trials and not only to Phase 0

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