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Underlying this metabolic reprogramming is the abnormal activation of core transcription factors such as HIF-1 and NF-B, which regulate the expression of genes related to glycolysis, amino acid catabolism, and fatty acid oxidation, respectively ( Table 1 Overview of relevant metabolites and their normal functions in COPD

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10.1016/j.redox.2017.09.009 [DOI] [PMC free article] [PubMed] [Google Scholar] Berzosa C., Cebrin I., Fuentes-Broto L., Gmez-Trulln E., Piedrafita E., Martnez-Ballarn E., et al

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