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The rs2231142 variant of the ABCG2 gene is associated with uric acid levels and gout among Japanese people

While the expression pattern of the three AtGSTUs was similar in rosette and root tissues, with expression being enhanced by exposure to IDF, but not after treatment with FFA alone, the magnitude of their induction was clearly much lower in shoot tissue than in root tissue

Substitutions of Tyr-274 by glutamate, cysteine or histidine remain enzymatically active insofar as cleaving the duplex DNA, but religation does not occur since the 3'-phosphodiester bond doesn't form, it requires the OH of Tyr-274

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doi:10.1210/jc.2018-02385 Alizadeh M, Karandish M, Asghari Jafarabadi M, et al

The halogenated cysteine S -conjugates, but not the corresponding mercapturates, are bioactivated by -lyases (Background: Bioactivation of Halogenated Alkenes section)