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further reported that poliumoside counteracts HGHF-induced bone degradation and ferroptosis by activating the NRF2/GPX4 signaling pathway, suggesting its potential as a novel therapeutic approach for T2DM-associated osteoporosis [176]

Research has documented reduced fat mass, decreased adipocyte size, and shifts in adipose tissue gene expression patterns toward fat-mobilizing rather than fat-storing phenotypes

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[DOI] [PubMed] [Google Scholar] 32.Sproul D., Meehan R.R

Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury