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The infusion rate must be controlled to prevent bad reactions

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If irritation persists, discontinue use

Ishikawa M, Takayanagi G, Sasaki K (1988) Effect of buthionine sulfoximine, an inhibitor of glutathione biosynthesis, on the selenium-induced lethality in mice

However, since NO is freely diffusible across membranes, it is possible that the mitochondrial production of peroxynitrite may derive from extramitochondrial NO diffusing into mitochondria to react with superoxide generated by ETC
