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Subcutaneous injection in the vicinity of an injured tendon or muscle provides both local and systemic effects, maximizing exposure where healing is most needed while still distributing the compound throughout the body

Indeed, a recent whole-transcriptome sequencing study in humans demonstrated the presence of progesterone receptor membrane component 2 (PGRMC2) and nuclear progesterone receptor gene expressions within the SGCC 35 , suggesting the possibility of direct effects of progesterone on SGCC neurons

[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Trammell S
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