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The activation of VEGFR-2 and dissociation from VE-cadherin is regulated by a Src-dependent process that can be induced by tensile strains on pulmonary artery ECs ( Models to Study VEGFR-2 Signaling As it is highly difficult to control independent biomechanical forces in in vivo models, most of what we know about VEGFR-2 mechanotransduction comes from in vitro systems

Through cleavage of dynamic phenylboronic ester bonds under ROS stimulation 62 , the hydrogel demonstrated ROS-sensitive drug release behavior, as evidenced by the 90% cumulative release of D-CuP within 72 h under H 2 O 2 stimulation (Fig

doi: 10.1007/BF02088582

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Lichtman, A