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Other studies have demonstrated that forced head-to-tail fusion can disrupt interdomain cooperativity, leading to reduced binding avidity or unintended steric clashes that compromise biological activity 18,19
The hyper pigmentation has already lightened significantly
& Vercellotti, G
[DOI] [PubMed] [Google Scholar] 12.Prescott LF
[PMC free article: PMC5451581] [PubMed: 28314764] 94
