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After 2 months, most patients showed at least some improvement and at the 1-year follow-up, over 70% of patients still showed improvement

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Krekels EH, Danhof M, Tibboel D et al , Ontogeny of hepatic glucuronidation

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Of note the prolonged treatment with BSO did not substantially affect the weight of treated mice, suggesting limited undesired effects associated with this regimen

Doses can be reduced or titration slowed