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Chaperone-mediated autophagy: a unique way to enter the lysosome world

Rare risks include copper toxicity, particularly in individuals with underlying conditions such as Wilsons disease (a genetic disorder causing copper accumulation), and theoretical concerns regarding angiogenesis promotion in the context of active cancers

These data also reinforce the view that the local production of insulin/IGFs is the major intratesticular signal regulating SC number, testis size and sperm output in mammals

However, that may also limit patient enrollment in clinical trials

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Biomedicines 9(11):1614 Sweeney MD, Sagare AP, Zlokovic BV (2018) Bloodbrain barrier breakdown in Alzheimer disease and other neurodegenerative disorders