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[94] Clinical Diagnosis: Repeated sun exposure promotes the development of recurrent blisters and erosions, with secondary infections that may result in severe scarring, sclerodermatous change, and deformities of the hand.[95] Sclerodactyly, osteolysis and shortening of the phalanges, and progressive joint deformities can occur as well

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Sources: [1] FAIS, G., MANCA, A., BOLOGNESI, F., BORSELLI, M., CONCAS, A., BUSUTTI, M., BROGGI, G., SANNA, P., CASTILLO-ALEMAN, Y.M., RIVERO-JIMNEZ, R.A., BENCOMO-HERNANDEZ, A.A., VENTURA-CARMENATE, Y., ALTEA, M., PANTALEO, A., GABRIELLI, G., BIGLIOLI, F., CAO, G., GIANNACCARE, G

31 In a recent study, PASE was also validated in Asian population, with acceptable testretest reliability (intraclass correlation coefficient =0.81)

Prolonged phenobarbitone exposure results in induction of hepatocellular neoplasms in mice and rats (Greaves 2007