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Despite the difficulties in carrying out prospective studies specifically investigating the use of silymarin for this condition brought on by mushroom poisoning, the administration of a parenterally administered silibininbased formulation is the preferred treatment approach in cases of amatoxininduced liver failure (Fu et al., 2022)

Furthermore, HDL and apoA-I protect against atherosclerosis by reducing inflammation via mechanisms independent of cholesterol efflux (31,75) (see details below)