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4550 For instance, carriers of heterozygous gene variants in the leptinmelanocortin pathway (in seven different genes: LEPR , PCSK1 , POMC , SH2B1 , SRC1 , MC4R and SIM1 ) showed significant weight regain after RYGB in the medium and long term, although they initially demonstrated effective weight loss

In this case, the urinary wasting of other compounds, such as bicarbonate, phosphorus and amino acids, allows a net differentiation, since patients with primary carnitine deficiency have selective carnitine losses [3]

Vtizou et al., 2015)