glutathione iron sulfur cluster Protocellular Heme and Iron–Sulfur Clusters 4Fe-4S] glutathione cluster | C40H60Fe4N12O24S8-6
Description
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Determination of the Neurospora crassa CYS 3 sulfur regulatory protein consensus DNA-binding site: amino-acid substitutions in the CYS3 bZIP domain that alter DNA-binding specificity
![glutathione iron sulfur cluster Protocellular Heme and IronSulfur Clusters 4Fe-4S] glutathione cluster | C40H60Fe4N12O24S8-6](https://journals.asm.org/cms/10.1128/mBio.02425-21/asset/776917b8-5ae5-46e3-8854-f40ff116fbe9/assets/images/medium/mbio.02425-21-f004.gif)
While further studies are needed to assess longterm safety, dosing, and clinical relevance, the work points to a promising intranasal drugdelivery platform that emphasizes stability, retention, and neuroprotectionkey considerations for managing a chronic neurodegenerative disease
![glutathione iron sulfur cluster Protocellular Heme and IronSulfur Clusters 4Fe-4S] glutathione cluster | C40H60Fe4N12O24S8-6](https://media.springernature.com/m685/springer-static/image/art%3A10.1007%2Fs00775-018-1548-6/MediaObjects/775_2018_1548_Fig1_HTML.gif)
Zhou Y, Danbolt NC
![glutathione iron sulfur cluster Protocellular Heme and IronSulfur Clusters 4Fe-4S] glutathione cluster | C40H60Fe4N12O24S8-6](https://www.jic.ac.uk/app/uploads/2023/07/j1.png)
However, more evidence is needed to support this specific relationship along with further studies directed towards the effects of modulating levels of GSH on immune cell activity and programming in the CNS
![glutathione iron sulfur cluster Protocellular Heme and IronSulfur Clusters 4Fe-4S] glutathione cluster | C40H60Fe4N12O24S8-6](https://www.degruyterbrill.com/document/doi/10.1515/hsz-2020-0237/asset/graphic/j_hsz-2020-0237_fig_001.jpg)
Clinical efficacy and safety of dotinurad, a novel selective urate reabsorption inhibitor, in Japanese hyperuricemic patients with or without gout: randomized, multicenter, double-blind, placebo-controlled, parallel-group, confirmatory phase 2 study
![glutathione iron sulfur cluster Protocellular Heme and IronSulfur Clusters 4Fe-4S] glutathione cluster | C40H60Fe4N12O24S8-6](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e29/2574672/47cf5490bde5/nihms59361f1.jpg)