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Description
The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)
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Consult your healthcare professional if pregnant, breastfeeding or taking medication
The 8mg dose achieved 22.8% reduction, and even the 4mg dose reached 21.1%
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Riedel B, Lim J, Brauer K, Shaw A, Reardon M, Rice D
