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The onset of these symptoms, generally 24 hours or more after the transdermal system has been removed, can be severe and may require medical intervention [see Warnings and Precautions (5.6)]

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Its k cat / K m values toward tyrosine and DOPA are 600 and 181 s 1 mM 1 , respectively, which are 2.78- and 1.79-fold higher than the WT enzyme

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With generalized convulsions, severe brain lesion and hyperammonemia and increased serum enzyme values already at 25 min post-paracetamol, it seems that toxins can rapidly reach the brain and affect its function, even before major liver lesions might appear, unless BPC 157 was given

Hence, they require gentle treatment