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[DOI] [PMC free article] [PubMed] [Google Scholar] 28.Martens CR, Denman BA, Mazzo MR, et al

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Gaps in safety assessment encompass limited long-term data in vulnerable populations, an incomplete understanding of horizontal gene transfer related to antimicrobial resistance, and uncertainty regarding the systemic impact of prolonged microbiome modulation, particularly with next-generation strains lacking a long history of safe use (142)

One of the primary endogenous sources of free radicals is the mitochondrial electron transport chain (ETC) [3]