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The mitochondria became shorter and rounder, with their internal structures appearing more irregular and incomplete (Fig

Certain pain medicationsparticularly opioidscan increase pain sensitivity over time through a process known as opioid-induced hyperalgesia

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Abbreviations BBB: Blood-brain barrier BER: Berberine CS: Chitosan DMSO: Dimethyl sulfoxide EE %: Percentage entrapment efficiency GFAB: Glial fibrillary acid protein GSH: Reduced glutathione IHC: Immunohistochemistry MAO-B: Monoamine oxidase B MPTP/P: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine PDI: Polydispersity index PD: Parkinsons disease SOD: Superoxide dismutase TEM: Transmission electron microscopy TNF-: Tumor necrosis factor alpha References Cheng Z, Kang C, Che S, Su J, Sun Q, Ge T, Guo Y, Lv J, Sun Z, Yang W, Li B, Li X, Cui R

Nature 333 , 635640 (1988)

The peptide's possible role in promoting the healing of damaged gastrointestinal tissues, supporting neurological integrity, and protecting organs from injury positions it as a compelling candidate for further study in the search for new research interventions
