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Our investigation identifies new potentially druggable locations in the receptor, expanding the existing repertoire of functionally relevant sites for the rational design of novel GLP-1R allosteric modulators based on the modulation of receptor-cholesterol interactions

These moves may improve accessibility for patients currently using these medications off-label for addiction

Although not enough to offset the high cost of the GLP-1 drugs themselves, GLP-1s are having an impact on cost

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